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KMID : 0366220100450040224
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Korean Journal of Hematology
2010 Volume.45 No. 4 p.224 ~ p.235
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The immunobiology of cord blood transplantation
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Szabolcs Paul
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Abstract
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Despite significant recent advances in the applicability and outcome following unrelated cord blood transplantation (UCBT), infections remain a major cause of mortality associated with poor immune recovery in the first 6 months after UCBT. Enhanced immune reconstitution not only could improve survival by reduced transplant related mortality, but may also favorably impact on relapse incidence by improved graft-versus-leukemia effects. This review will summarize our current understanding of the biology of immune recovery post-UCBT with an emphasis on adaptive T cell dependent immunity. New efforts to boost immunity will be also highlighted including our own laboratory, where ex vivo T cell expansion is pursued towards adoptive immunotherapy.
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KEYWORD
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Cord blood stem cell transplantation, Opportunistic infection, Immune reconstitution, Adoptive immunotherapy, Graft vs leukemia effect
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